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KMID : 0614019990150010232
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Journal of Pharmaceutical Sciences (C.N.U.)
1999 Volume.15 No. 1 p.232 ~ p.237
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Antitumor and Antileukopenic Activity of HCA, the Protein-polysaccharide Fraction of Cultured Mycelia of Hebeloma crustuliniforme
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Cho Kyung-Joo
Chung Kyeong-Soo
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Abstract
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A protein-polysaccharide fraction was isolated from the mycelial culture of a Korean basidiomycetous fungus, Hebeloma crustuliniforme, and was named HCA(Hebeloma crustuliniforme fraction A). When intraperitoneally injected at 200mg/kg/day once daily for 10 days, HCA inhibited the growth of sarcoma 180 solid tumor in ICR mice by 65.1%(p<0.05). HCA also exerted protective effect against leukopenia induced by cyclophosphamide with the protection ratio of 39.7%(p<0.01).
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KEYWORD
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Hebeloma crustuliniforme, polysaccharide, HCA, antitumor, antileukopenic
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